TileCache provides a Python-based WMS-C/TMS server, with pluggable caching mechanisms and rendering backends. In the simplest use case, TileCache requires only write access to a disk, the ability to run Python CGI scripts, and a WMS you want to be cached. With these resources, you can create your own local disk-based cache of any WMS server, and use the result in any WMS-C supporting client, like OpenLayers, or any TMS supporting client, like OpenLayers and worldKit. Note that you might need py-paste if you want to use Tilecache through WSGI or FastCGI, and/or py-memcached if you plan to use a Memcached caching backend. See http://tilecache.org/docs/README for details.
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